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Cornea and grafts

Cornea and grafts

The cornea is a transparent structure at the front of the eye that plays an essential role in vision. When it loses its transparency or its regularity, vision can be significantly impaired. Corneal grafting is a common, standardised procedure that today gives excellent results thanks to advances in surgical technique.

What is it?

The endothelium is the innermost layer of the cornea, responsible for maintaining a constant level of hydration by pumping excess fluid out of the corneal stroma, thereby preserving its transparency. When these cells deteriorate, the cornea thickens and loses its clarity, causing a progressive decline in vision. DMEK (Descemet Membrane Endothelial Keratoplasty) replaces only this thin damaged layer with a healthy graft, without touching the rest of the cornea. In certain more complex cases, a DSAEK (Descemet Stripping Automated Endothelial Keratoplasty) is performed instead.

Most frequent indications

  • Fuchs’ dystrophy
  • Pseudophakic bullous keratopathy

What are the signs of endothelial disease?

  • Vision that becomes progressively clouded, often more marked in the morning
  • Sensitivity to light and a halo around light sources
  • A sensation of fog that does not improve with glasses
  • In advanced forms, eye pain related to corneal oedema

How does the surgery work?

The procedure is performed in an operating theatre. The very thin graft is introduced into the eye and positioned against the inner surface of the cornea, where it is held in place by an air bubble injected at the end of the procedure.

Key points after surgery

  • Remain strictly on your back for 3 days, so that the air bubble holds the graft in place
  • Apply eye drops as prescribed (anti-rejection, antibiotic)
  • Avoid rubbing the eye
  • Close follow-up appointments during the first days to monitor graft attachment

What is it?

Unlike the endothelial graft, which replaces only a thin layer of the cornea, the penetrating graft replaces all the layers of the cornea, through its full thickness, with a complete graft. It is indicated when the corneal disease affects several layers at once and cannot be treated by a partial graft.

Most frequent indications

  • Advanced keratoconus
  • Extensive corneal scarring (post-infectious, post-traumatic)
  • Failure of a previous graft

How does the surgery work?

The procedure is performed in an operating theatre. The graft is cut to the size of the recipient cornea, then sutured in place with very fine stitches that generally remain in place for several months to several years.

Key points after surgery

  • Apply eye drops as prescribed (anti-rejection, antibiotic), often over a prolonged period
  • Avoid rubbing the eye and any pressure on the operated eye
  • Protect the eye (protective shield) as prescribed
  • Regular follow-up appointments to monitor healing and the gradual removal of the sutures

What is it?

Keratoconus is a corneal disease characterised by progressive thinning and deformation of the cornea, which takes on a cone shape instead of its regular curvature. This deformation causes irregular astigmatism and a loss of vision that is not always well corrected by conventional glasses. Keratoconus often begins in adolescence or young adulthood and may progress over several years.

What are the signs?

  • Progressive loss of vision, often asymmetrical between the two eyes
  • Astigmatism that increases or changes frequently
  • Double or distorted vision, including with glasses
  • Increased sensitivity to light

Corneal cross-linking

A treatment intended to stabilise the cornea by strengthening the bonds between the collagen fibres, using vitamin B2 (riboflavin) activated by ultraviolet light. It does not correct the existing deformation but prevents its progression. It is offered as early as possible after diagnosis, as long as the keratoconus is progressing. Cross-linking may be combined with a PTK (therapeutic keratectomy) or a PRK (photorefractive keratectomy), or even both, according to the patient’s needs.

Key points after surgery

  • Apply eye drops as prescribed (anti-inflammatory, antibiotic)
  • Avoid rubbing the eye
  • Wear a clear protective contact lens during the first days
  • Follow-up appointments to monitor stabilisation of the cornea